南宫NG28

      南宫NG28 /诊断试剂 /热门肿瘤标志物 /TMB /bTMB-P1 (22.91) Reference Standard

      bTMB-P1 (22.91) Reference Standard

      CBP80001-10

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      I. Background

      Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials. 

       

      Sample ID

      Cat.No.

      Format

      Background

      Assay

      Comments

      DC20030079

      CBP80001-10N

      gDNA

      B lymphoblast, Female

      500x WES

      Same individual

      DC20030078

      CBP80001-10T

      ctDNA (Enzymatic digestion)

      stage 4, adenocarcinoma Lung, Female

      IDT xGenExome Research Panel v1.0捕获,Target Region 39M, Probe Region 51M,CDS Region 33.52M;
      HiSeq X-TEN,af选择0.02 cut off,再过滤。

      DC20030078 is 100% Tumor sample and DC20030079 is 100% Normal sample.

       

       

       

      Cut off =1%

      Cut off =2%

      Cut off =3%

      Cut off =4%

      Cut off =5%

      Mutation Number

      769

      768

      734

      720

      713

      TMB value

      22.91

      22.91

      21.90

      21.48

      21.27

      Data Download

      DC20030078.filter.0.0.01.tag.maf

      DC20030078.filter.0.0.02.tag.maf

      DC20030078.filter.0.0.03.tag.maf

      DC20030078.filter.0.0.04.tag.maf

      DC20030078.filter.0.0.05.tag.maf

       

       
       
       
       

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