PDGFRA CHO
CBP74621
询 价
索取Protocol
产品描述
产品数据库
| I. Background | |
| PDGFRA(血小板衍生生长因子受体α)是一种III型受体酪氨酸激酶,由PDGFRA基因编码。它作为细胞表面受体,能与PDGFA、PDGFB等配体结合,顺利获得二聚化和自身磷酸化激活下游信号通路,在胚胎发育、伤口愈合、细胞增殖与迁移中发挥关键作用。该基因突变与胃肠道间质瘤(GIST)、黑色素瘤等多种癌症相关,也是重要的临床治疗靶点。 | |
| II. Description | |
| PDGFRA CHO细胞,在 CHO-K1 细胞的基础上,稳定表达 PDGFRA 。 | |
| III. Introduction | |
| Expressed gene: | PDGFRA |
| Host Cell: | CHO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+ 5 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
Figure 1. Recombinant PDGFRA CHO constitutively expressing PDGFRA. |
|